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Title   Cisplatin과 Etoposide 주사용액의 안정성에 관한 연구 ( Stability of Cisplatin and Etoposide in Normal Solotion )
Publicationinfo   1997 Jan; 029(04): 700-706.
Key_word   Cisplatin, Etoposide, Stability, Acqueous solution.
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Abstract   Purpose: The cisplatin and etoposide had been reported to be an effective anti-tumor drug for small cell lung cancer, ovarian cancer, breast cancer and so on. The aim of this study was to evaluate the stability of cisplatin and etoposide in aqueous solution. Materials and Methods: Cisplatin 200 pg/ml was prepared in 0.9% sodium chloride and stored in either glass bottle or polyvinyl chloride(pvc) bag and protected from light or exposed to fluorescent light. Etoposide solution was prepared in 0.9% sodium chloride, and contained in glass bottle. Precipitating concentration was achieved using 200 ug/ml, 400 ug/ml, 600 ug/ml, and 1000 ug/ml of etoposide solution. Samples were stored at room temperature and visually inspected and assayed for etoposide and cisplatin content by high-performance liquid chromatography after 15 minutes, 2, 4, 8, 12, 16 and 24 hours of storage. Result: 1) Cisplatin concentration decreased less than 10% from initial concentration for 24 hours of storage, both in glass bottle and pvc bag. Stability of cisplatin 200 ug/ml in both container were not different. and Condition of light exposure did not have sig- nificant effect on stability of cisplatin 200 ug/ml in glass bottle. 2) The etoposide 200 ug/ml was not precipitated and stable for 24 hours, but we could find the precipitates of etoposide with the concentration of 400 ug/ml or higher for 24 hours. Conclusion: Cisplatin 200 ug/ml and etoposide 200 ug/ml in 0.9% sodium chloride were stable at room temperature under room fluorescent light for 24 hours.
저 자   오상철(Sang Cheol Oh),김영미(Young Mi Kim),유영인(Young In Yoo),조송자(Song Ja Cho),김병수(Byung Soo Kim),신상원(Sang Won Shin),김열홍(Yeol Hong Kim),김준석(Joon Seok Kim),